Release Profile
Designed for methylphenidate release
throughout the day1
Featuring multi-layer release beads and a biphasic pharmacokinetic profile, Adhansia XR combines attributes of an IR and ER in one capsule.1
IR=immediate release; ER=extended release.
Pharmacokinetic data do not correlate to clinical efficacy.
Watch how the multi-layer release (MLR™) technology works
Within the once-daily capsule, each bead releases the dose in two phases1-3
One methylphenidate dose is released immediately, and one is released later1-3
Not shown in actual size or color.
Outermost
Layer
Methylphenidate HCl layer
- Contains ~20% of the methylphenidate dose
- Water-soluble (dissolves upon contact with GI fluid); designed for immediate release
Delayed-release coating
- pH dependent; dissolves when the GI environment pH is ≥7
Controlled-release coating
- Controlled-release polymer that becomes permeable in the GI tract
Methylphenidate HCl layer
- Contains ~80% of the methylphenidate dose, which gradually diffuses through the controlled-release polymer
Sugar sphere
- Core of the bead upon which ~80% of the methylphenidate dose is layered
Innermost
Layer
Biphasic release throughout your patients' day1,2
Adhansia XR produces an initial peak concentration, and a subsequent prolonged peak that tapers off thereafter1,2
Pharmacokinetic data do not correlate to clinical efficacy.
MEAN CONCENTRATION-TIME PROFILES FOR d,l-METHYLPHENIDATE ON DAY 5 (DAILY DOSING) IN ADULTS 18+ YEARS1,2*
Cmax=maximum plasma concentration.
*Evaluated in 21 healthy adults under fasted conditions for 5 consecutive days. Steady state achieved from Day 3.1,2
†Median (range) times to 1st Cmax=1.5 (1-2.5) hours and 2nd Cmax=12 (8.5-16) hours.1,2
Adhansia XR contains a racemic mixture of d- and l‑methylphenidate.1,2